Genomics

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Biography

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Richard Charles "Dick" Lewontin (born March 29, 1929) is an American evolutionary biologist, geneticist and social commentator. A leader in developing the mathematical basis of population genetics and evolutionary theory, he pioneered the notion of using techniques from molecular biology such as gel electrophoresis to apply to questions of genetic variation and evolution. In a pair of 1966 papers co-authored with J.L. Hubby in the journal Genetics, Lewontin helped set the stage for the modern field of molecular evolution.

Lewontin was born in New York City. Lewontin attended Forest Hills High School and the Ecole Libre des Hautes Etudes in New York. In 1951, he obtained a bachelors degree in biology from Harvard University. In 1952, he received a master's degree in mathematical statistics followed by a doctorate in zoology in 1954, both from Columbia University. Lewontin held faculty positions at North Carolina State University, the University of Rochester, and the University of Chicago. In 1973 Lewontin served as Alexander Agassiz Professor of Zoology and Professor of Biology at Harvard until 1998 and as of 2003 was the Alexander Agassiz Research Professor at Harvard. Lewontin has worked with and had great influence on many philosophers of biology, including Elliott Sober, Philip Kitcher, Peter Godfrey-Smith, and Robert Brandon, often inviting them to work in his lab.

Work

Lewontin and his late Harvard colleague Stephen Jay Gould introduced the use of the architectural word "spandrel" in an evolutionary context, in an influential 1979 paper "The spandrels of San Marco and the Panglossion paradigm: a critique of the adaptationist programme", using it for a feature of an organism that exists as a necessary consequence of other features and is not actually selected for. The relative frequency of spandrels, so defined, versus adaptive features in nature, remains a controversial topic in evolutionary biology.

Lewontin was an early proponent of a hierarchy of levels of selection in his article "The Units of Selection". He has been a major influence on philosophers of biology, notably William Wimsatt, who taught with Lewontin and Richard Levins at the University of Chicago, Robert Brandon, who studied with Lewontin as graduate student, Philip Kitcher, and Elliot Sober. Lewontin briefly argued for the historical nature of biological causality in "Is Nature Probable or Capricious."

In "Organism and Environment" in Scientia, and in more popular form in the last chapter of Biology as Ideology, Lewontin argued that while traditional Darwinism has portrayed the organism as passive receiver of environmental influences, a correct understanding should emphasize the organism as an active constructer of its environment. Niches are not pre-formed, empty receptacles into which organisms are inserted, but are defined and created by organisms. The organism-environment relationship is reciprocal and dialectical. M.W. Feldman, K.N. Laland, and F.J. Odling-Smee among others have developed Lewontin's conception in more detailed models.

Lewontin has long been a critic of traditional neo-Darwinian approaches to adaptation. In his article "Adaptation" in the Italian Encyclopedia Einaudi and in a toned-down version in Scientific American he emphasized the need to give an engineering characterization of adaptation separate from measurement of number of offspring, rather than simply assuming organs or organisms are at adaptive optima. Lewontin has claimed that his more general, technical criticism of adaptationism grew out of his recognition that the fallacies of sociobiology reflect fundamentally flawed assumptions of adaptiveness of all traits in much of the modern evolutionary synthesis.

Sociobiology and evolutionary psychology

Along with others, such as Gould, Lewontin has been a persistent critic of some themes in neo-Darwinism; specifically, he has criticised sociobiologists and evolutionary psychologists such as Edward O. Wilson and Richard Dawkins, who attempt to explain animal behaviour and social structures in terms of evolutionary advantage or strategy—this has been controversial when applied to humans, because some see it as genetic determinism. Lewontin, in his writing, calls for what he considers a more nuanced view of evolution, which he claims requires a more careful understanding of the context of the whole organism as well as the environment.

Such concerns about what he views as the oversimplification of genetics led Lewontin to be a frequent commentator in debates, and he has lectured widely to promote his views on evolutionary biology and science. In books such as 'Not in Our Genes' (co-authored with Steven Rose and Leon J. Kamin) and numerous articles, Lewontin has questioned much of the claimed heritability of human behavioral traits such as intelligence as measured by IQ tests, promoted by books such as 'The Bell Curve'.

Lewontin has been criticized by some academics for a rejection of sociobiology for non-scientific reasons. Some credit this rejection to political beliefs (Wilson 1995) (Lewontin has at times identified himself as Marxist or at least left-leaning). Others (Kitcher 1985) have countered that Lewontin's criticisms of sociobiology are genuine scientific concerns about the discipline and claim that attacking Lewontin's motives amount to an ad hominem argument. Researchers such as Steven Pinker (2002) address Lewontin's concerns in a scientific context, but nevertheless believe that Lewontin is attacking a straw man version of sociobiology (or its more modern incarnation as evolutionary psychology) and therefore claim that his arguments miss the target.

Agribusiness

Lewontin has also written on the economics of agribusiness. He has contended that hybrid corn was developed and propagated not because of its superior quality, but because it allowed agribusiness corporations to force farmers to buy new seed each year rather than plant seed produced by their previous crop of corn. Lewontin testified in an unsuccessful suit in California challenging the state's financing of research to develop automatic tomato pickers, favoring the profits of agribusiness over the employment of farm workers.

'Lewontin's Folly'

Lewontin, in a 1972 paper, The apportionment of human diversity and again in a 1974 book, The Genetic Basis of Evolutionary Change, argues that because the probability of racial misclassification of an individual based on variation in a single genetic locus is approximately 30% that race is an invalid taxonomic construct.

Human Genetic Diversity: Lewontin's Fallacy is an academic paper published in 2003 by A.W.F. Edwards that attacks the conclusion of Richard Lewontin that race is an invalid taxonomic construct.

Edwards argues that when one takes into account more loci, the probability of racial misclassification rapidly approaches 0%. (See Figure 1) Edwards argues that the information which distinguishes races is "hidden in the correlation structure of the data."

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Figure 1.

Edwards argues that both ordination and cluster analyses can reveal the correlation structure of multilocus data.

A caricature of Lewontin's argument is that because humans share 50% of their DNA with carrots, we must be 50% the same

"In popular articles that play down the genetical differences among human populations, it is often stated that about 85% of the total genetical variation is due to individual differences within populations and only 15% to differences between populations or ethnic groups. It has therefore been proposed that the division of Homo sapiens into these groups is not justified by the genetic data. This conclusion, due to R.C. Lewontin in 1972, is unwarranted because the argument ignores the fact that most of the information that distinguishes populations is hidden in the correlation structure of the data and not simply in the variation of the individual factors." (1)

Bibliography

  • "Is Nature Probable or Capricious?" Bio Science, vol. 16, (1966) 25-27.
  • "The Units of Selection," Annual Reviews of Ecology and Systematics, vol. 1 (1970) 1-18.
  • "The Apportionment of Human Diversity," Evolutionary Biology, vol. 6 (1972) pp. 391-398.
  • The Genetic Basis of Evolutionary Change, Columbia University Press, (1974) ISBN 0-231-03392-3 (alternate, search)
  • "Adattamento," Enciclopedia Einnaudi, (1977) vol. 1, 198-214.
  • "Adaptation," Scientific American, vol. 239, (1978) 212-228.
  • Gould, S.J., and Richard Lewontin (1979). "The spandrels of San Marco and the Panglossion paradigm: a critique of the adaptationist programme". Proc R Soc Lond B 205: 581-598.
  • Human Diversity, Scientific American Library (1982) 2d edn 1995 ISBN 0-716-76013-4 (alternate, search)
  • "The Organism as Subject and Object of Evolution," Scientia vol. 188 (1983) 65-82.
  • Not in Our Genes: Biology, Ideology and Human Nature (with Steven Rose and Leon J. Kamin) (1984) ISBN 0-394-72888-2 (alternate, search)
  • The Dialectical Biologist (with Richard Levins), Harvard University Press (1985) ISBN 0-674-20283-X (alternate, search)
  • Biology as Ideology: The Doctrine of DNA (1991) ISBN 0-060-97519-9 (alternate, search)
  • The Triple Helix: Gene, Organism, and Environment, Harvard University Press (2000) ISBN 0-674-00159-1 (alternate, search)

Links

Attribution


1. Edwards AW. Human genetic diversity: Lewontin's fallacy. Bioessays. 2003 Aug;25(8):798-801.

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